Special
areas in the pancreas gland, the Islets of Langerhans, produce a hormone called
insulin. This hormone is a protein of small size. Insulin stimulates muscle
cells and other body cells to take up glucose from the blood and convert the
glucose to glycogen, a kind of starch, and then store the glycogen. By need the
body cells convert the glycogen to glucose and use it as fuel. In this way
insulin keeps the glucose level in the blood at a normal size.
By
diabetes type 2, the cells in the body do not react properly by stimulation
from insulin. Therefore they do not take in enough glucose from the blood to
store it or to use it as energy source. This condition is called insulin
resistance. The amount of glucose in the blood therefore rises. Also the
insulin production can rise to regulate the glucose amount down, but this
effort to reduce the blood glucose is not effective enough. If the disease
persists for many years, the insulin production may tire out, so that the
amount of secreted insulin decreases.
THE
CAUSES AND MECHANISMS OF DIABETES TYPE 2
The
exact mechanism that causes the disease is not known. There may be an
autoimmune response to insulin or to the molecules on the cell surfaces that
the insulin connects to. However, these lifestyle factors can cause the
disease:
-Too
high consume of sugar and fat
-Over-weight
-Too
less exercise over many years.
Therefore
diabetes type 2 can be prevented by a right diet and with regular exercise.
When
the glucose uptake into the body cells is reduced, but glucose instead
accumulates in the blood, the following physiological effects occur:
-The
body cells do not get enough fuel for the work they shall do.
-The
molecular thickness (osmality) of the blood increases. This causes water to be
pulled out from the body tissues and into the blood. The tissues thus get dried
out and the urine production increases.
-The
tissues begin to break down protein and fat to get energy, causing weight loss
and muscular reduction.
The
symptoms of diabetes type 2 are a consequence of these mechanisms.
THE
SYMPTOMS OF DIABETES TYPE 2
Diabetes
type 2 is the most common kind of diabetes, actually 10 times more common than
diabetes type 1, where the insulin production is reduced or stopped. The
disease usually appears after the age of 50, but the high sugar and fat consume
in western countries nowadays also causes young persons to acquire the disease.
Symptoms of diabetes type 2 come gradually. The symptoms are.
-Increased
urine production
-Dehydration,
that is a lack of water in the body
-Abnormal
high thirst
-Dry
mouth
-Increased
appetite
-Slow
healing of physical injuries
-Itching
in the skin
-Infections
caused by yeasts
-Impaired
vision
In
the long turn, the disease can cause atherosclerosis with blood vessel
narrowing, heart disease and stroke.
LIFESTYLE
TREATMENT OF DIABETES TYPE 2
The
treatment of diabetes type 2 is most often diet with a low sugar and fat
amount, and with the amount of sugar and carbohydrates strictly controlled. A
weight reduction program is a part of the treatment for over-weighted persons.
An exercise program is also an important component of the treatment, both in
order to get rid of excessive blood sugar levels and to loose weight.
A
general healthy diet will also help. Such a diet contains food sources like
fish, fouls, seafood, mushrooms, whole corn cereals, whole corn bread and
vegetables. The following fat and sugar containing food types are recommended
in moderate amounts: Nuts, almonds, sunflower seeds, eggs, spawn and fruit.
These
fat types are also recommended in moderate amounts: Olive oil, walnut oil, rape
oil, sunflower oil. Soy oil, corn oil and butter can be used in small amounts,
but these fat types should not be your only fat source. If you only use these
fat types, you will not get all essential fatty acids that the body need to
work properly. Things to be avoided in the diet are: Snacks, fast food, fat
read meat, cookies, margarine, chemically altered fat and sweet beverages.
The
listed measures will usually lighten the burden upon the blood sugar control of
the body so that it manages to normalize the blood sugar levels.
The
listed lifestyle measures will also prevent diabetes type 2, but for prevention
the control of the daily carbohydrate intake does not have to be controlled so
strictly.
MEDICAL
TREATMENT OF DIABETES TYPE 2
If
lifestyle measures do not work good enough, medication to lower the blood sugar
is used. There are several classes of medicaments against diabetes type 2 to be
taken by mouth and that work in different ways:
-The
first class of drugs against diabetes type 2 developed, and which are still in
use, are the sulfonylureas drugs like Glucotrol® and Micronase®. These drugs
stimulate the pancreas to make more insulin. Side effects from these drugs that
may occur are: Low blood sugar levels, water retention, edema, weight gain,
heart problems and allergic reactions. Law blood sugar levels occur more easily
if the drug is used together with alcohol.
-The
biguanides like Metformin make the liver to slow down the brakedown of stored
complex carbohydrates to glucose, and thus lower the blood glucose level. This
drug class also help to control weight. Possible side effects form this drug
class are lactic acidosis, nausea, appetite loss, diarrhea, abdominal gas and
metallic taste.
-Alpha-Glucosidase
Inhibitors like Precose® and Glyset®, inhibit breakdown of complex
carbohydrates in the gut to simple sugars and the uptake of sugars from the gut
into the blood, and thus lower the content of sugar in the blood. They may give
side effects like abdominal gas and diarrhea.
-The
thiazolidinediones like Avandia® and Actos® make body cells more sensitive to
insulin and thus make skeletal muscle take up glucose form the blood. Side
effects that may occur by this class of drugs are anaemia, head-aches, muscle
aches, tooth aches, sore throut, increased upper respiratory tract infection
rate, water retention, edema, weight gain, heart problems and liver injury.
-Meglitinides
like Prandin® are taken by meals and controls the blood sugar levels after
meals by stimulating the pancreas to make more insulin when the sugar from the
meal comes into the blood. Possible side effects are low blood sugar levels,
increased risk of upper respiratory tract infection, headache, joint and back
pain, nausea, diarrhea, constipation and weight gain.
If
the insulin production is reduced, insulin injections are also used.
There
are also natural products in the market that can help to normalize the blood
sugar level by diabetes type 2. Those products cannot heal the disease, but
they can help the body to regulate the blood sugar. These products contain
minerals that are working components of enzymes that stimulate the glucose
metabolism in the body. They also contain herbs that have been used for a long
time in traditional medicine to regulate the glucose level and have proven
their effects in scientific studies.
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